Efficacy of Exosome Adipose-Derived Stem Cells (ACSs-Exosome) on Skin Flaps Transplantation in Plastic Surgery: A Systematic Literature Review

Background: Exosomes are a small subset of extracellular vesicles with size about 50 nm – 200 nm, which found in many body fluids. The exosome is rich various proteins and cargo that carries out the process transporting between cells context cell communication. This becomes potential new therapeutic modality triggering modulation activity target so ACSs-Exosome to modulate skin flap transplantation repair plastic surgery.
 Methods: literature search was carried databases (PubMed, Web Sciences, EMBASE, Cochrane Libraries, Google Scholar) regarding use ASCs-exosome surgery cases.
 Results: A total 5 studies were included this systematic review. In general, administration more effective percentage survival area than placebo group. There 3 state effectiveness 70 percent compared group, only range 30-40 percent.
 Conclusion: has be developed improve rate case surgery.